Ontology highlight
ABSTRACT:
SUBMITTER: Michaud NR
PROVIDER: S-EPMC3502238 | biostudies-literature | 2012 Nov-Dec
REPOSITORIES: biostudies-literature
Michaud Neil R NR Jani Jitesh P JP Hillerman Stephen S Tsaparikos Konstantinos E KE Barbacci-Tobin Elsa G EG Knauth Elisabeth E Putz Henry H Campbell Mary M Karam George A GA Chrunyk Boris B Gebhard David F DF Green Larry L LL Xu Jinghai J JJ Dunn Margaret C MC Coskran Tim M TM Lapointe Jean-Martin JM Cohen Bruce D BD Coleman Kevin G KG Bedian Vahe V Vincent Patrick P Kajiji Shama S Steyn Stefan J SJ Borzillo Gary V GV Los Gerrit G
mAbs 20120924 6
The c-Met proto-oncogene is a multifunctional receptor tyrosine kinase that is stimulated by its ligand, hepatocyte growth factor (HGF), to induce cell growth, motility and morphogenesis. Dysregulation of c-Met function, through mutational activation or overexpression, has been observed in many types of cancer and is thought to contribute to tumor growth and metastasis by affecting mitogenesis, invasion, and angiogenesis. We identified human monoclonal antibodies that bind to the extracellular d ...[more]