Ontology highlight
ABSTRACT:
SUBMITTER: Schmitz MH
PROVIDER: S-EPMC3839080 | biostudies-other | 2010 Sep
REPOSITORIES: biostudies-other
Schmitz Michael H A MH Held Michael M Janssens Veerle V Hutchins James R A JR Hudecz Otto O Ivanova Elitsa E Goris Jozef J Trinkle-Mulcahy Laura L Lamond Angus I AI Poser Ina I Hyman Anthony A AA Mechtler Karl K Peters Jan-Michael JM Gerlich Daniel W DW
Nature cell biology 20100815 9
When vertebrate cells exit mitosis various cellular structures are re-organized to build functional interphase cells. This depends on Cdk1 (cyclin dependent kinase 1) inactivation and subsequent dephosphorylation of its substrates. Members of the protein phosphatase 1 and 2A (PP1 and PP2A) families can dephosphorylate Cdk1 substrates in biochemical extracts during mitotic exit, but how this relates to postmitotic reassembly of interphase structures in intact cells is not known. Here, we use a li ...[more]