Ontology highlight
ABSTRACT:
SUBMITTER: Klesney-Tait J
PROVIDER: S-EPMC3533287 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Klesney-Tait Julia J Keck Kathy K Li Xiaopeng X Gilfillan Susan S Otero Karel K Baruah Sankar S Meyerholz David K DK Varga Steven M SM Knudson Cory J CJ Moninger Thomas O TO Moreland Jessica J Zabner Joseph J Colonna Marco M
The Journal of clinical investigation 20121217 1
Acute respiratory infections are responsible for more than 4 million deaths each year. Neutrophils play an essential role in the innate immune response to lung infection. These cells have an armamentarium of pattern recognition molecules and antimicrobial agents that identify and eliminate pathogens. In the setting of infection, neutrophil triggering receptor expressed on myeloid cells 1 (TREM-1) amplifies inflammatory signaling. Here we demonstrate for the first time that TREM-1 also plays an i ...[more]