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Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product.

ABSTRACT: Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.

SUBMITTER: Kim EJ

PROVIDER: S-EPMC3536539 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product.

Kim Eun Ji EJ Lee Jong Hyun JH Choi Hyukjae H Pereira Alban R AR Ban Yeon Hee YH Yoo Young Ji YJ Kim Eunji E Park Je Won JW Sherman David H DH Gerwick William H WH Yoon Yeo Joon YJ

Organic letters 20121113 23

Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products. ...[more]

PMID: 23148802

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