Ontology highlight
ABSTRACT:
SUBMITTER: Lewellis SW
PROVIDER: S-EPMC3563679 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Lewellis Stephen W SW Nagelberg Danielle D Subedi Abhi A Staton Alison A LeBlanc Michelle M Giraldez Antonio A Knaut Holger H
The Journal of cell biology 20130201 3
During animal development, SDF1 simultaneously guides various cell types to different targets. As many targets are in close proximity to one another, it is unclear how the system avoids mistargeting. Zebrafish trigeminal sensory neurons express the SDF1 receptor Cxcr4b and encounter multiple SDF1 sources during migration, but ignore all but the correct one. We show that miR-430 and Cxcr7b regulation of SDF1a are required for precise guidance. In the absence of miR-430 or Cxcr7b, neurons responde ...[more]