Ontology highlight
ABSTRACT:
SUBMITTER: Genest O
PROVIDER: S-EPMC3570620 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Genest Olivier O Reidy Michael M Street Timothy O TO Hoskins Joel R JR Camberg Jodi L JL Agard David A DA Masison Daniel C DC Wickner Sue S
Molecular cell 20121220 3
The heat shock protein 90 (Hsp90) family of heat shock proteins is an abundantly expressed and highly conserved family of ATP-dependent molecular chaperones. Hsp90 facilitates remodeling and activation of hundreds of proteins. In this study, we developed a screen to identify Hsp90-defective mutants in E. coli. The mutations obtained define a region incorporating residues from the middle and C-terminal domains of E. coli Hsp90. The mutant proteins are defective in chaperone activity and client bi ...[more]