Dataset Information

Association between TNF ? gene polymorphisms and the risk of duodenal ulcer: a meta-analysis.

ABSTRACT: BACKGROUND: Epidemiological studies have evaluated the association between tumor necrosis factor ? (TNF-?) single nucleotide polymorphisms (SNPs) and duodenal ulcer (DU), but the results remain inconclusive. The aim of this study was to perform a meta-analysis to investigate a more authentic association between TNF-? SNPs and DU. METHODS: We performed the meta-analysis by searching PubMed, Embase, and Web of Science databases from the first available year to Sep. 5, 2012. Additionally, checking reference lists from identified articles, reviews, and the abstracts presented at related scientific societies meetings were also performed. All case-control studies investigating the association between TNF-? SNPs and DU risk were included. The association was assessed by odds ratio (OR) with 95% confidence interval (CI). Publication bias was analyzed by Begg's funnel plot and Egger's regression test. RESULTS: A total of sixteen studies reporting TNF-? -308G/A, -1031T/C, -863C/A, -857C/T, and -238G/A polymorphism were included in our final meta-analysis. There was no statistically significant association between -308G/A polymorphism and DU in the overall study population, as well as subgroup analyses by ethnicity, study design, and H. pylori status. As for -1031T/C, -863C/A, -857C/T, and -238G/A, results of our meta-analyses showed no statistical evidence of significant association. Power calculation on the combined sample size showed that the statistical powers were all lower than 80% for all the meta-analyses. CONCLUSIONS: The data suggests that there is no statistical evidence of significant association between the studied TNF-? SNPs and DU. However, this conclusion should be interpreted with caution as low statistical powers were revealed by power calculations. In future, larger sample-size studies with homogeneous DU patients and well-matched controls are required.

SUBMITTER: Zhang BB

PROVIDER: S-EPMC3579801 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Association between TNF α gene polymorphisms and the risk of duodenal ulcer: a meta-analysis.

Zhang Bei-Bei BB Liu Xing-Zhen XZ Sun Jin J Yin Yan-Wei YW Sun Qian-Qian QQ

PloS one 20130222 2

<h4>Background</h4>Epidemiological studies have evaluated the association between tumor necrosis factor α (TNF-α) single nucleotide polymorphisms (SNPs) and duodenal ulcer (DU), but the results remain inconclusive. The aim of this study was to perform a meta-analysis to investigate a more authentic association between TNF-α SNPs and DU.<h4>Methods</h4>We performed the meta-analysis by searching PubMed, Embase, and Web of Science databases from the first available year to Sep. 5, 2012. Additional ...[more]

PMID: 23451177

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Project description:BACKGROUND AND OBJECTIVE:Insulin-like growth factor 1 (IGF1) gene three prime untranslated region (3'-UTR) polymorphisms have been reported to be associated with cancer risk. However, the conclusions of the relevant studies are not consistent. The present meta-analysis evaluates the relationship between IGF1 gene 3'-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk. METHODS:Articles regarding the relationship between IGF1 rs5742714, rs6214, and rs6220 polymorphisms and cancer risk were selected by searching the PubMed, Embase, and Web of Science databases before April 30, 2018. Altogether, we obtained 34 case-controlled studies from 20 articles, including 21,568 cases and 31,199 controls. The strength of associations was quantified using odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). RESULTS:In the present meta-analysis, no significant associations were detected between rs5742714, rs6214, and rs6220 and overall cancer risk. Thus, in stratified analyses, we found that rs6214 was associated with a significantly reduced risk of breast cancer under the allele, heterozygote, and dominant models (A vs G: OR, 0.94, 95% CI,0.88-1.00, P?=?.044; GA vs GG: OR, 0.88, 95% CI, 0.80-0.97, P?=?.012; AA?+?GA vs GG: OR, 0.89, 95% CI, 0.81-0.97, P?=?.011), as well as pancreatic cancer under the recessive model (AA vs GA?+?GG: OR, 0.68, 95% CI,0.53-0.87, P?=?.003). Also, rs6220 was associated with a significantly increased risk of breast cancer under the homozygote model (GG vs AA: OR, 1.23, 95% CI, 1.02-1.48, P?=?.031). In addition, rs6220 was found to increase overall cancer risk among Caucasians under the allele model (G vs A: OR, 1.06, 95% CI, 1.00-1.13, P?=?.043). CONCLUSIONS:In this meta-analysis, we investigated and reviewed the relationship between IGF1 gene 3'-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk based on present epidemiological studies. Further studies are needed to draw more precise conclusions in the future.

Dataset Information

Association between TNF ? gene polymorphisms and the risk of duodenal ulcer: a meta-analysis.

Publications

Association between TNF α gene polymorphisms and the risk of duodenal ulcer: a meta-analysis.

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