Polymer crowders and protein crowders act similarly on protein folding stability.
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ABSTRACT:
SUBMITTER: Zhou HX
PROVIDER: S-EPMC3581760 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Polymer crowders and protein crowders act similarly on protein folding stability.
FEBS letters 20130123 5
Recently a polymer crowder and two protein crowders were found to have opposite effects on the folding stability of chymotrypsin inhibitor 2 (CI2), suggesting that they interact differently with CI2. Here we propose that all the macromolecular crowders act similarly, with an entropic component favoring the folded state and an enthalpic component favoring the unfolded state. The net effect is destabilizing below a crossover temperature but stabilizing above it. This general trend is indeed observ ...[more]
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