Ontology highlight
ABSTRACT:
SUBMITTER: Montanez-Wiscovich ME
PROVIDER: S-EPMC3600378 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Montañez-Wiscovich Marjorie E ME Shelton Melissa D MD Seachrist Darcie D DD Lozada Kristen L KL Johnson Emhonta E Miedler John D JD Abdul-Karim Fadi W FW Visvader Jane E JE Keri Ruth A RA
The Journal of pathology 20101101 3
The LIM-only protein, LMO4, is a transcriptional modulator overexpressed in breast cancer. It is oncogenic in murine mammary epithelium and is required for G2/M progression of ErbB2-dependent cells as well as growth and invasion of other breast cancer cell types. However, the mechanisms underlying the oncogenic activity of LMO4 remain unclear. Herein, we show that LMO4 is expressed in all breast cancer subtypes examined and its expression level correlates with the degree of proliferation of such ...[more]