Ontology highlight
ABSTRACT:
SUBMITTER: Buschleb M
PROVIDER: S-EPMC3605497 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Amino acids 20120523 6
The non-proteinogenic amino acids capreomycidine and epicapreomycidine are constituents of antibiotically active natural products, but the synthesis of these unusual cyclic guanidine derivatives is challenging. The biosynthesis of capreomycidine has therefore been employed as a guideline to develop a concise biomimetic synthesis of both epimeric amino acids. The resulting domino-guanidinylation-aza-Michael-addition reaction provides the most convenient access to these amino acids in racemic form ...[more]