Ontology highlight
ABSTRACT:
SUBMITTER: Beziat V
PROVIDER: S-EPMC3617633 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Béziat Vivien V Liu Lisa L LL Malmberg Jenny-Ann JA Ivarsson Martin A MA Sohlberg Ebba E Björklund Andreas T AT Retière Christelle C Sverremark-Ekström Eva E Traherne James J Ljungman Per P Schaffer Marie M Price David A DA Trowsdale John J Michaëlsson Jakob J Ljunggren Hans-Gustaf HG Malmberg Karl-Johan KJ
Blood 20130116 14
Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a given NK cell is genetically hard-wired, we hypothesized that KIR repertoire perturbations reflect expansions of unique NK-cell subsets and may be used to trace adaptation of the NK-cell compartment to virus infections. By determining the human "KIR-ome" at a single-cell level in more than 200 donors, we were able ...[more]