Ontology highlight
ABSTRACT:
SUBMITTER: Gao X
PROVIDER: S-EPMC3625983 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Gao Xin X Woo Sang Kook SK Krische Michael J MJ
Journal of the American Chemical Society 20130306 11
The 14-membered macrolide 6-deoxyerythronolide B is prepared in 14 steps (longest linear sequence) and 20 total steps. Two different methods for alcohol CH-crotylation via transfer hydrogenation are deployed for the first time in target-oriented synthesis. Enyne metathesis is used to form the 14-membered ring. The present approach represents the most concise construction of any erythronolide reported, to date. ...[more]