Unknown

Dataset Information

0

Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron.


ABSTRACT: Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neuron (CSDn). The CSDn spreads its termini all over the contralateral antennal lobe, suggesting a diffuse neuromodulatory role. A closer examination, however, reveals a restricted pattern of the CSDn arborization in some glomeruli. We show that sensory neuron-derived Eph interacts with Ephrin in the CSDn, to regulate these arborizations. Behavioural analysis of animals with altered Eph-ephrin signaling and with consequent arborization defects suggests that neuromodulation requires local glomerular-specific patterning of the CSDn termini. Our results show the importance of developmental regulation of terminal arborization of even the diffuse modulatory neurons to allow them to route sensory-inputs according to the behavioural contexts.

SUBMITTER: Singh AP 

PROVIDER: S-EPMC3630106 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Sensory neuron-derived eph regulates glomerular arbors and modulatory function of a central serotonergic neuron.

Singh Ajeet Pratap AP   Das Rudra Nayan RN   Rao Gururaj G   Aggarwal Aman A   Diegelmann Soeren S   Evers Jan Felix JF   Karandikar Hrishikesh H   Landgraf Matthias M   Rodrigues Veronica V   Vijayraghavan K K  

PLoS genetics 20130418 4


Olfactory sensory neurons connect to the antennal lobe of the fly to create the primary units for processing odor cues, the glomeruli. Unique amongst antennal-lobe neurons is an identified wide-field serotonergic neuron, the contralaterally-projecting, serotonin-immunoreactive deutocerebral neuron (CSDn). The CSDn spreads its termini all over the contralateral antennal lobe, suggesting a diffuse neuromodulatory role. A closer examination, however, reveals a restricted pattern of the CSDn arboriz  ...[more]

Similar Datasets

| S-EPMC4426395 | biostudies-literature
| S-EPMC5600294 | biostudies-literature
2024-08-04 | GSE239596 | GEO
| S-EPMC2605652 | biostudies-literature
| S-EPMC7030926 | biostudies-literature
| S-EPMC406485 | biostudies-literature
| S-EPMC3411591 | biostudies-literature
| S-EPMC4703328 | biostudies-literature
| S-EPMC9428938 | biostudies-literature
| S-EPMC5701122 | biostudies-literature