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Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans.

ABSTRACT: Evidence indicates that individuals with the 5-HTTLPR variant short/short genotype have increased sensitivity to both positive and negative perceptions of perceived social support. The aim of this study was to evaluate this association among Veterans in the context of mild traumatic brain injury (TBI). As part of a larger TBI center, we performed a cross-sectional study of 67 OEF/OIF/OND Veterans (41 with TBI and 26 controls without TBI) who completed the questionnaires and consented to genetic testing. The primary measures included the Connor-Davidson Resilience Scale (CDRISC) and the Perceived Limitations in community participation subscale of the Community Reintegration of Service Members Instrument (CRIS-PL). Both 5-HTTLPR genotype and TBI status were independently associated with the CRIS-PL (p = .009 for genotype, p = .001 for TBI) and the CDRISC (p = .015 for genotype, p = .003 for TBI) scores. This study suggests that both the 5-HTTLPR genotype and TBI status independently, in an almost equal but opposite direction, influence resilience and perceived limitations to social participation. Further, resilience appears more sensitive to perceived limitations in Veterans carrying an S'S' genotype than in L' carriers, but only in the context of having sustained a TBI. While having a TBI appeared to increase a Veteran's sensitivity to social stress, the Veteran's who were L' allele carriers with a TBI fared the worst, with lower resilience and more perceived limitations for community participation compared to L' carrier Veterans without a TBI or Veterans with the S'S' genotype regardless of TBI status.

SUBMITTER: Graham DP

PROVIDER: S-EPMC3643301 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans.

Graham David P DP Helmer Drew A DA Harding Mark J MJ Kosten Thomas R TR Petersen Nancy J NJ Nielsen David A DA

Journal of psychiatric research 20130308 6

Evidence indicates that individuals with the 5-HTTLPR variant short/short genotype have increased sensitivity to both positive and negative perceptions of perceived social support. The aim of this study was to evaluate this association among Veterans in the context of mild traumatic brain injury (TBI). As part of a larger TBI center, we performed a cross-sectional study of 67 OEF/OIF/OND Veterans (41 with TBI and 26 controls without TBI) who completed the questionnaires and consented to genetic ...[more]

PMID: 23478049

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Project description:As few studies have examined the relationship between the apolipoprotein E (APOE) gene and clinical outcomes after military-related traumatic brain injury (TBI), we aimed to determine whether the ?4 allele of the APOE gene influences neuropsychiatric symptoms in veterans with a history of mild-to-moderate TBI. Participants included 133 veterans (TBI?=?79; military controls [MC]?=?54) who underwent APOE genotyping and were divided into ?4+ (TBI?=?18; MC?=?15) and ?4- (TBI?=?61; MC?=?39) groups. All participants underwent evaluation of psychological distress using the Beck Depression Inventory-II, Beck Anxiety Inventory, and PTSD Checklist-Military Version. Two-way analyses of variance were conducted to examine the effect of group (TBI vs. MC) and APOE-?4 status (?4+ vs. ?4-) across symptom measures. There was a significant main effect of group across all symptom measures (TBI > MC; all p values <0.001), no main effect of ?4 genotype (p?=?0.152-0.222), and a significant interaction of group by ?4 genotype across all measures (p?=?0.027-0.047). Specifically, for TBI participants, ?4+ veterans demonstrated significantly higher symptom scores across all measures when compared to ?4- veterans (p?=?0.007-0.015). For MC participants, ?4 status had no effect on the severity of psychiatric symptom scores (p?=?0.585-0.708). Our results demonstrate that, in our well-characterized sample of veterans with history of neurotrauma, possession of the ?4 allele conveys risk for increased symptomatology (i.e., depression, anxiety, and post-traumatic stress disorder), even well outside of the acute phase of injury. Findings suggest a meaningful relationship between APOE genotype and psychiatric distress post-TBI, and they suggest that there is a brain basis for the complex neuropsychiatric presentation often observed in this vulnerable population. Future longitudinal studies are needed in order to further our understanding of how genetic factors influence response to TBI.

Dataset Information

Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans.

Publications

Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans.

Similar Datasets

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