Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.
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ABSTRACT:
SUBMITTER: Nikolova YS
PROVIDER: S-EPMC4146649 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.
Nikolova Yuliya S YS Koenen Karestan C KC Koenen Karestan C KC Galea Sandro S Wang Chiou-Miin CM Seney Marianne L ML Sibille Etienne E Williamson Douglas E DE Hariri Ahmad R AR
Nature neuroscience 20140803 9
We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robu ...[more]
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