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Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.

ABSTRACT: Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.

SUBMITTER: Melero I

PROVIDER: S-EPMC3653776 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature

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Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.

Melero Ignacio I Martinez-Forero Ivan I Dubrot Juan J Suarez Natalia N Palazón Asis A Chen Lieping L

Clinical cancer research : an official journal of the American Association for Cancer Research 20090224 5

Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand. ...[more]

PMID: 19240168

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