Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC3655769 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Chen Xufeng X Wong Jeffrey Y C JY Wong Patty P Radany Eric H EH
Molecular cancer research : MCR 20110208 4
Histone deacetylase inhibitors (HDI) have shown promise as candidate radiosensitizers for many types of cancers, including prostate cancer. However, the mechanisms of action are not well understood. In this study, we show in prostate cancer cells that valproic acid (VPA) at low concentrations has minimal cytotoxic effects yet can significantly increase radiation-induced apoptosis. VPA seems to stabilize a specific acetyl modification (lysine 120) of the p53 tumor suppressor protein, resulting in ...[more]