Ontology highlight
ABSTRACT:
SUBMITTER: Jeon AH
PROVIDER: S-EPMC3663554 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Jeon Amy Hye Won AH Böhm Christopher C Chen Fusheng F Huo Hairu H Ruan Xueying X Ren Carl He CH Ho Keith K Qamar Seema S Mathews Paul M PM Fraser Paul E PE Mount Howard T J HT St George-Hyslop Peter P Schmitt-Ulms Gerold G
The Journal of biological chemistry 20130415 21
γ-Secretase plays a pivotal role in the production of neurotoxic amyloid β-peptides (Aβ) in Alzheimer disease (AD) and consists of a heterotetrameric core complex that includes the aspartyl intramembrane protease presenilin (PS). The human genome codes for two presenilin paralogs. To understand the causes for distinct phenotypes of PS paralog-deficient mice and elucidate whether PS mutations associated with early-onset AD affect the molecular environment of mature γ-secretase complexes, quantita ...[more]