Ontology highlight
ABSTRACT:
SUBMITTER: Bialopiotrowicz E
PROVIDER: S-EPMC7139810 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Białopiotrowicz Emilia E Noyszewska-Kania Monika M Kachamakova-Trojanowska Neli N Łoboda Agnieszka A Cybulska Magdalena M Grochowska Aleksandra A Kopczyński Michał M Mikula Michał M Prochorec-Sobieszek Monika M Firczuk Małgorzata M Graczyk-Jarzynka Agnieszka A Zagożdżon Radosław R Ząbek Adam A Młynarz Piotr P Dulak Józef J Górniak Patryk P Szydłowski Maciej M Pyziak Karolina K Martyka Justyna J Sroka-Porada Agnieszka A Jabłońska Ewa E Polak Anna A Kowalczyk Piotr P Szumera-Ciećkiewicz Anna A Chapuy Bjoern B Rzymski Tomasz T Brzózka Krzysztof K Juszczyński Przemysław P
Cancers 20200303 3
Burkitt lymphoma (BL) is a rapidly growing tumor, characterized by high anabolic requirements. The <i>MYC</i> oncogene plays a central role in the pathogenesis of this malignancy, controlling genes involved in apoptosis, proliferation, and cellular metabolism. Serine biosynthesis pathway (SBP) couples glycolysis to folate and methionine cycles, supporting biosynthesis of certain amino acids, nucleotides, glutathione, and a methyl group donor, S-adenosylmethionine (SAM). We report that BLs overex ...[more]