Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
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ABSTRACT:
SUBMITTER: Bojesen SE
PROVIDER: S-EPMC3670748 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
Bojesen Stig E SE Pooley Karen A KA Johnatty Sharon E SE Beesley Jonathan J Michailidou Kyriaki K Tyrer Jonathan P JP Edwards Stacey L SL Pickett Hilda A HA Shen Howard C HC Smart Chanel E CE Hillman Kristine M KM Mai Phuong L PL Lawrenson Kate K Stutz Michael D MD Lu Yi Y Karevan Rod R Woods Nicholas N Johnston Rebecca L RL French Juliet D JD Chen Xiaoqing X Weischer Maren M Nielsen Sune F SF Maranian Melanie J MJ Ghoussaini Maya M Ahmed Shahana S Baynes Caroline C Bolla Manjeet K MK Wang Qin Q Dennis Joe J McGuffog Lesley L Barrowdale Daniel D Lee Andrew A Healey Sue S Lush Michael M Tessier Daniel C DC Vincent Daniel D Bacot Françis F Vergote Ignace I Lambrechts Sandrina S Despierre Evelyn E Risch Harvey A HA González-Neira Anna A Rossing Mary Anne MA Pita Guillermo G Doherty Jennifer A JA Alvarez Nuria N Larson Melissa C MC Fridley Brooke L BL Schoof Nils N Chang-Claude Jenny J Cicek Mine S MS Peto Julian J Kalli Kimberly R KR Broeks Annegien A Armasu Sebastian M SM Schmidt Marjanka K MK Braaf Linde M LM Winterhoff Boris B Nevanlinna Heli H Konecny Gottfried E GE Lambrechts Diether D Rogmann Lisa L Guénel Pascal P Teoman Attila A Milne Roger L RL Garcia Joaquin J JJ Cox Angela A Shridhar Vijayalakshmi V Burwinkel Barbara B Marme Frederik F Hein Rebecca R Sawyer Elinor J EJ Haiman Christopher A CA Wang-Gohrke Shan S Andrulis Irene L IL Moysich Kirsten B KB Hopper John L JL Odunsi Kunle K Lindblom Annika A Giles Graham G GG Brenner Hermann H Simard Jacques J Lurie Galina G Fasching Peter A PA Carney Michael E ME Radice Paolo P Wilkens Lynne R LR Swerdlow Anthony A Goodman Marc T MT Brauch Hiltrud H Garcia-Closas Montserrat M Hillemanns Peter P Winqvist Robert R Dürst Matthias M Devilee Peter P Runnebaum Ingo I Jakubowska Anna A Lubinski Jan J Mannermaa Arto A Butzow Ralf R Bogdanova Natalia V NV Dörk Thilo T Pelttari Liisa M LM Zheng Wei W Leminen Arto A Anton-Culver Hoda H Bunker Clareann H CH Kristensen Vessela V Ness Roberta B RB Muir Kenneth K Edwards Robert R Meindl Alfons A Heitz Florian F Matsuo Keitaro K du Bois Andreas A Wu Anna H AH Harter Philipp P Teo Soo-Hwang SH Schwaab Ira I Shu Xiao-Ou XO Blot William W Hosono Satoyo S Kang Daehee D Nakanishi Toru T Hartman Mikael M Yatabe Yasushi Y Hamann Ute U Karlan Beth Y BY Sangrajrang Suleeporn S Kjaer Susanne Krüger SK Gaborieau Valerie V Jensen Allan A Eccles Diana D Høgdall Estrid E Shen Chen-Yang CY Brown Judith J Woo Yin Ling YL Shah Mitul M Azmi Mat Adenan Noor MA Luben Robert R Omar Siti Zawiah SZ Czene Kamila K Vierkant Robert A RA Nordestgaard Børge G BG Flyger Henrik H Vachon Celine C Olson Janet E JE Wang Xianshu X Levine Douglas A DA Rudolph Anja A Weber Rachel Palmieri RP Flesch-Janys Dieter D Iversen Edwin E Nickels Stefan S Schildkraut Joellen M JM Silva Isabel Dos Santos Idos S Cramer Daniel W DW Gibson Lorna L Terry Kathryn L KL Fletcher Olivia O Vitonis Allison F AF van der Schoot C Ellen CE Poole Elizabeth M EM Hogervorst Frans B L FB Tworoger Shelley S SS Liu Jianjun J Bandera Elisa V EV Li Jingmei J Olson Sara H SH Humphreys Keith K Orlow Irene I Blomqvist Carl C Rodriguez-Rodriguez Lorna L Aittomäki Kristiina K Salvesen Helga B HB Muranen Taru A TA Wik Elisabeth E Brouwers Barbara B Krakstad Camilla C Wauters Els E Halle Mari K MK Wildiers Hans H Kiemeney Lambertus A LA Mulot Claire C Aben Katja K KK Laurent-Puig Pierre P Altena Anne Mvan AM Truong Thérèse T Massuger Leon F A G LF Benitez Javier J Pejovic Tanja T Perez Jose Ignacio Arias JI Hoatlin Maureen M Zamora M Pilar MP Cook Linda S LS Balasubramanian Sabapathy P SP Kelemen Linda E LE Schneeweiss Andreas A Le Nhu D ND Sohn Christof C Brooks-Wilson Angela A Tomlinson Ian I Kerin Michael J MJ Miller Nicola N Cybulski Cezary C Henderson Brian E BE Menkiszak Janusz J Schumacher Fredrick F Wentzensen Nicolas N Le Marchand Loic L Yang Hannah P HP Mulligan Anna Marie AM Glendon Gord G Engelholm Svend Aage SA Knight Julia A JA Høgdall Claus K CK Apicella Carmel C Gore Martin M Tsimiklis Helen H Song Honglin H Southey Melissa C MC Jager Agnes A den Ouweland Ans M Wvan AM Brown Robert R Martens John W M JW Flanagan James M JM Kriege Mieke M Paul James J Margolin Sara S Siddiqui Nadeem N Severi Gianluca G Whittemore Alice S AS Baglietto Laura L McGuire Valerie V Stegmaier Christa C Sieh Weiva W Müller Heiko H Arndt Volker V Labrèche France F Gao Yu-Tang YT Goldberg Mark S MS Yang Gong G Dumont Martine M McLaughlin John R JR Hartmann Arndt A Ekici Arif B AB Beckmann Matthias W MW Phelan Catherine M CM Lux Michael P MP Permuth-Wey Jenny J Peissel Bernard B Sellers Thomas A TA Ficarazzi Filomena F Barile Monica M Ziogas Argyrios A Ashworth Alan A Gentry-Maharaj Aleksandra A Jones Michael M Ramus Susan J SJ Orr Nick N Menon Usha U Pearce Celeste L CL Brüning Thomas T Pike Malcolm C MC Ko Yon-Dschun YD Lissowska Jolanta J Figueroa Jonine J Kupryjanczyk Jolanta J Chanock Stephen J SJ Dansonka-Mieszkowska Agnieszka A Jukkola-Vuorinen Arja A Rzepecka Iwona K IK Pylkäs Katri K Bidzinski Mariusz M Kauppila Saila S Hollestelle Antoinette A Seynaeve Caroline C Tollenaar Rob A E M RA Durda Katarzyna K Jaworska Katarzyna K Hartikainen Jaana M JM Kosma Veli-Matti VM Kataja Vesa V Antonenkova Natalia N NN Long Jirong J Shrubsole Martha M Deming-Halverson Sandra S Lophatananon Artitaya A Siriwanarangsan Pornthep P Stewart-Brown Sarah S Ditsch Nina N Lichtner Peter P Schmutzler Rita K RK Ito Hidemi H Iwata Hiroji H Tajima Kazuo K Tseng Chiu-Chen CC Stram Daniel O DO van den Berg David D Yip Cheng Har CH Ikram M Kamran MK Teh Yew-Ching YC Cai Hui H Lu Wei W Signorello Lisa B LB Cai Qiuyin Q Noh Dong-Young DY Yoo Keun-Young KY Miao Hui H Iau Philip Tsau-Choong PT Teo Yik Ying YY McKay James J Shapiro Charles C Ademuyiwa Foluso F Fountzilas George G Hsiung Chia-Ni CN Yu Jyh-Cherng JC Hou Ming-Feng MF Healey Catherine S CS Luccarini Craig C Peock Susan S Stoppa-Lyonnet Dominique D Peterlongo Paolo P Rebbeck Timothy R TR Piedmonte Marion M Singer Christian F CF Friedman Eitan E Thomassen Mads M Offit Kenneth K Hansen Thomas V O TV Neuhausen Susan L SL Szabo Csilla I CI Blanco Ignacio I Garber Judy J Narod Steven A SA Weitzel Jeffrey N JN Montagna Marco M Olah Edith E Godwin Andrew K AK Yannoukakos Drakoulis D Goldgar David E DE Caldes Trinidad T Imyanitov Evgeny N EN Tihomirova Laima L Arun Banu K BK Campbell Ian I Mensenkamp Arjen R AR van Asperen Christi J CJ van Roozendaal Kees E P KE Meijers-Heijboer Hanne H Collée J Margriet JM Oosterwijk Jan C JC Hooning Maartje J MJ Rookus Matti A MA van der Luijt Rob B RB Os Theo A Mvan TA Evans D Gareth DG Frost Debra D Fineberg Elena E Barwell Julian J Walker Lisa L Kennedy M John MJ Platte Radka R Davidson Rosemarie R Ellis Steve D SD Cole Trevor T Bressac-de Paillerets Brigitte B Buecher Bruno B Damiola Francesca F Faivre Laurence L Frenay Marc M Sinilnikova Olga M OM Caron Olivier O Giraud Sophie S Mazoyer Sylvie S Bonadona Valérie V Caux-Moncoutier Virginie V Toloczko-Grabarek Aleksandra A Gronwald Jacek J Byrski Tomasz T Spurdle Amanda B AB Bonanni Bernardo B Zaffaroni Daniela D Giannini Giuseppe G Bernard Loris L Dolcetti Riccardo R Manoukian Siranoush S Arnold Norbert N Engel Christoph C Deissler Helmut H Rhiem Kerstin K Niederacher Dieter D Plendl Hansjoerg H Sutter Christian C Wappenschmidt Barbara B Borg Ake A Melin Beatrice B Rantala Johanna J Soller Maria M Nathanson Katherine L KL Domchek Susan M SM Rodriguez Gustavo C GC Salani Ritu R Kaulich Daphne Gschwantler DG Tea Muy-Kheng MK Paluch Shani Shimon SS Laitman Yael Y Skytte Anne-Bine AB Kruse Torben A TA Jensen Uffe Birk UB Robson Mark M Gerdes Anne-Marie AM Ejlertsen Bent B Foretova Lenka L Savage Sharon A SA Lester Jenny J Soucy Penny P Kuchenbaecker Karoline B KB Olswold Curtis C Cunningham Julie M JM Slager Susan S Pankratz Vernon S VS Dicks Ed E Lakhani Sunil R SR Couch Fergus J FJ Hall Per P Monteiro Alvaro N A AN Gayther Simon A SA Pharoah Paul D P PD Reddel Roger R RR Goode Ellen L EL Greene Mark H MH Easton Douglas F DF Berchuck Andrew A Antoniou Antonis C AC Chenevix-Trench Georgia G Dunning Alison M AM
Nature genetics 20130401 4
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates wi ...[more]
