Identifying RNA editing sites using RNA sequencing data alone.
Ontology highlight
ABSTRACT:
SUBMITTER: Ramaswami G
PROVIDER: S-EPMC3676881 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Identifying RNA editing sites using RNA sequencing data alone.
Ramaswami Gokul G Zhang Rui R Piskol Robert R Keegan Liam P LP Deng Patricia P O'Connell Mary A MA Li Jin Billy JB
Nature methods 20130106 2
We show that RNA editing sites can be called with high confidence using RNA sequencing data from multiple samples across either individuals or species, without the need for matched genomic DNA sequence. We identified many previously unidentified editing sites in both humans and Drosophila; our results nearly double the known number of human protein recoding events. We also found that human genes harboring conserved editing sites within Alu repeats are enriched for neuronal functions. ...[more]
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