Ontology highlight
ABSTRACT:
SUBMITTER: Iwasaki YW
PROVIDER: S-EPMC3677259 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Iwasaki Yuka W YW Kiga Kotaro K Kayo Hiroyuki H Fukuda-Yuzawa Yoko Y Weise Jasmin J Inada Toshifumi T Tomita Masaru M Ishihama Yasushi Y Fukao Taro T
RNA (New York, N.Y.) 20130219 4
Proper regulation of gene expression during cell cycle entry ensures the successful completion of proliferation, avoiding risks such as carcinogenesis. The microRNA (miRNA) network is an emerging molecular system regulating multiple genetic pathways. We demonstrate here that the global elevation of miRNAs is critical for proper control of gene expression program during cell cycle entry. Strikingly, Exportin 5 (XPO5) is promptly induced during cell cycle entry by a PI3K-dependent post-transcripti ...[more]