Ontology highlight
ABSTRACT:
SUBMITTER: Guo C
PROVIDER: S-EPMC3685183 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Guo Changying C Gerasimova Tatiana T Hao Haiping H Ivanova Irina I Chakraborty Tirtha T Selimyan Roza R Oltz Eugene M EM Sen Ranjan R
Cell 20111006 2
The immunoglobulin heavy-chain (IgH) gene locus undergoes radial repositioning within the nucleus and locus contraction in preparation for gene recombination. We demonstrate that IgH locus conformation involves two levels of chromosomal compaction. At the first level, the locus folds into several multilooped domains. One such domain at the 3' end of the locus requires an enhancer, Eμ; two other domains at the 5' end are Eμ independent. At the second level, these domains are brought into spatial ...[more]