Ontology highlight
ABSTRACT:
SUBMITTER: Chatterjee B
PROVIDER: S-EPMC3700907 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chatterjee Biswanath B Lee Chung-Yu CY Lin Chen C Chen Eric H-L EH Huang Chao-Li CL Yang Chien-Chih CC Chen Rita P-Y RP
PloS one 20130703 7
The principal event underlying the development of prion disease is the conversion of soluble cellular prion protein (PrP(C)) into its disease-causing isoform, PrP(Sc). This conversion is associated with a marked change in secondary structure from predominantly α-helical to a high β-sheet content, ultimately leading to the formation of aggregates consisting of ordered fibrillar assemblies referred to as amyloid. In vitro, recombinant prion proteins and short prion peptides from various species ha ...[more]