Ontology highlight
ABSTRACT:
SUBMITTER: Dore AS
PROVIDER: S-EPMC3732996 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Doré Andrew S AS Robertson Nathan N Errey James C JC Ng Irene I Hollenstein Kaspar K Tehan Ben B Hurrell Edward E Bennett Kirstie K Congreve Miles M Magnani Francesca F Tate Christopher G CG Weir Malcolm M Marshall Fiona H FH
Structure (London, England : 1993) 20110901 9
Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These effects are mediated primarily via blockade of adenosine receptors. Xanthine analogs with improved properties have been developed as potential treatments for diseases such as Parkinson's disease. Here we report the structures of a thermostabilized adenosine A(2A) receptor in complex with the xanthines xanthine amine congener and caffeine, as well as the A(2A) selective inv ...[more]