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Debye screening in single-molecule carbon nanotube field-effect sensors.

ABSTRACT: Point-functionalized carbon nanotube field-effect transistors can serve as highly sensitive detectors for biomolecules. With a probe molecule covalently bound to a defect in the nanotube sidewall, two-level random telegraph noise (RTN) in the conductance of the device is observed as a result of a charged target biomolecule binding and unbinding at the defect site. Charge in proximity to the defect modulates the potential (and transmission) of the conductance-limiting barrier created by the defect. In this Letter, we study how these single-molecule electronic sensors are affected by ionic screening. Both charge in proximity to the defect site and buffer concentration are found to affect RTN amplitude in a manner that follows from simple Debye length considerations. RTN amplitude is also dependent on the potential of the electrolyte gate as applied to the reference electrode; at high enough gate potentials, the target DNA is completely repelled and RTN is suppressed.

SUBMITTER: Sorgenfrei S

PROVIDER: S-EPMC3735439 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Debye screening in single-molecule carbon nanotube field-effect sensors.

Sorgenfrei Sebastian S Chiu Chien-Yang CY Johnston Matthew M Nuckolls Colin C Shepard Kenneth L KL

Nano letters 20110801 9

Point-functionalized carbon nanotube field-effect transistors can serve as highly sensitive detectors for biomolecules. With a probe molecule covalently bound to a defect in the nanotube sidewall, two-level random telegraph noise (RTN) in the conductance of the device is observed as a result of a charged target biomolecule binding and unbinding at the defect site. Charge in proximity to the defect modulates the potential (and transmission) of the conductance-limiting barrier created by the defec ...[more]

PMID: 21806018

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