Ontology highlight
ABSTRACT:
SUBMITTER: Marianes A
PROVIDER: S-EPMC3755342 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Marianes Alexis A Spradling Allan C AC
eLife 20130827
The Drosophila midgut is maintained throughout its length by superficially similar, multipotent intestinal stem cells that generate new enterocytes and enteroendocrine cells in response to tissue requirements. We found that the midgut shows striking regional differentiation along its anterior-posterior axis. At least ten distinct subregions differ in cell morphology, physiology and the expression of hundreds of genes with likely tissue functions. Stem cells also vary regionally in behavior and g ...[more]