Ontology highlight
ABSTRACT:
SUBMITTER: Fages J
PROVIDER: S-EPMC7351224 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
PLoS genetics 20200629 6
Ribosomal DNA (rDNA) is the most transcribed genomic region and contains hundreds of tandem repeats. Maintaining these rDNA repeats as well as the level of rDNA transcription is essential for cellular homeostasis. DNA damages generated in rDNA need to be efficiently and accurately repaired and rDNA repeats instability has been reported in cancer, aging and neurological diseases. Here, we describe that the histone demethylase JMJD6 is rapidly recruited to nucleolar DNA damage and is crucial for t ...[more]