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Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors.

ABSTRACT: A series of O-aryl- and alkyl-substituted phosphorodithioates were designed and synthesized as hydrogen sulfide (H2S) donors. H2S releasing capability of these compounds was evaluated using fluorescence methods. O-aryl substituted donors showed slow and sustained H2S release while O-alkylated compounds showed very weak H2S releasing capability. We also evaluated donors' protective effects against hydrogen peroxide (H2O2)-induced oxidative damage in myocytes and donors' toxicity toward B16BL6 mouse melanoma cells.

SUBMITTER: Park CM

PROVIDER: S-EPMC3789624 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors.

Park Chung-Min CM Zhao Yu Y Zhu Zhaohui Z Pacheco Armando A Peng Bo B Devarie-Baez Nelmi O NO Bagdon Powell P Zhang Hui H Xian Ming M

Molecular bioSystems 20131001 10

A series of O-aryl- and alkyl-substituted phosphorodithioates were designed and synthesized as hydrogen sulfide (H2S) donors. H2S releasing capability of these compounds was evaluated using fluorescence methods. O-aryl substituted donors showed slow and sustained H2S release while O-alkylated compounds showed very weak H2S releasing capability. We also evaluated donors' protective effects against hydrogen peroxide (H2O2)-induced oxidative damage in myocytes and donors' toxicity toward B16BL6 mou ...[more]

PMID: 23917226

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