Ontology highlight
ABSTRACT:
SUBMITTER: Duttwyler S
PROVIDER: S-EPMC3809088 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Duttwyler Simon S Chen Shuming S Takase Michael K MK Wiberg Kenneth B KB Bergman Robert G RG Ellman Jonathan A JA
Science (New York, N.Y.) 20130201 6120
Piperidines are prevalent in natural products and pharmaceutical agents and are important synthetic targets for drug discovery and development. We report on a methodology that provides highly substituted piperidine derivatives with regiochemistry selectively tunable by varying the strength of acid used in the reaction. Readily available starting materials are first converted to dihydropyridines via a cascade reaction initiated by rhodium-catalyzed carbon-hydrogen bond activation. Subsequent dive ...[more]