Ontology highlight
ABSTRACT:
SUBMITTER: Caillat C
PROVIDER: S-EPMC3814758 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Caillat Christophe C Pefani Dafni-Eleftheria DE Gillespie Peter J PJ Taraviras Stavros S Blow J Julian JJ Lygerou Zoi Z Perrakis Anastassis A
The Journal of biological chemistry 20130924 44
Geminin is an important regulator of proliferation and differentiation in metazoans, which predominantly inhibits the DNA replication licensing factor Cdt1, preventing genome over-replication. We show that Geminin preferentially forms stable coiled-coil heterodimers with its homologue, Idas. In contrast to Idas-Geminin heterodimers, Idas homodimers are thermodynamically unstable and are unlikely to exist as a stable macromolecule under physiological conditions. The crystal structure of the homol ...[more]