Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC381644 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Wang Lixin L Lin Chii-Mei CM Brooks Sarah S Cimbora Dan D Groudine Mark M Aladjem Mirit I MI
Molecular and cellular biology 20040401 8
Previous studies have shown that mammalian cells contain replicator sequences, which can determine where DNA replication initiates. However, the specific sequences that confer replicator activity were not identified. Here we report a detailed analysis of replicator sequences that dictate initiation of DNA replication from the human beta-globin locus. This analysis suggests that the beta-globin replication initiation region contains two adjacent, redundant replicators. Each replicator was capable ...[more]