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Total synthesis of (-)-epimyrtine by a gold-catalyzed hydroamination approach.

ABSTRACT: A new approach to the total synthesis of (-)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield.

SUBMITTER: Trinh TT

PROVIDER: S-EPMC3817515 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Total synthesis of (-)-epimyrtine by a gold-catalyzed hydroamination approach.

Trinh Thi Thanh Huyen TT Nguyen Khanh Hung KH de Aguiar Amaral Patricia P Gouault Nicolas N

Beilstein journal of organic chemistry 20131009

A new approach to the total synthesis of (-)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield. ...[more]

PMID: 24204417

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