Ontology highlight
ABSTRACT:
SUBMITTER: Qabazard B
PROVIDER: S-EPMC3832670 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20131108 11
Exogenous hydrogen sulfide (H2S) administration and endogenous H2S metabolism were explored in the nematode C. elegans. Chronic treatment with a slow-releasing H2S donor, GYY4137, extended median survival by 17-23% and increased tolerance towards oxidative and endoplasmic reticulum (ER) stress. Also, cysl-2, a sulfhydrylase/cysteine synthase in C. elegans, was transcriptionally upregulated by GYY4137 treatment and the deletion of cysl-2 resulted in a significant reduction in lifespan which was p ...[more]