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Marseillevirus adenitis in an 11-month-old child.

ABSTRACT: A Marseillevirus (giant virus of amoeba) has been found in the blood and stool samples of individuals who otherwise appear to be healthy. During an attempt to define a serological cutoff for Marseillevirus by enzyme-linked immunosorbent assay (ELISA) in children, we serendipitously detected high antibody responses to Marseillevirus in an 11-month-old boy suffering from adenitis. Marseillevirus DNA was then found in his blood using PCR and with a unique sequence. We identified Marseillevirus in a lymph node using fluorescence in situ hybridization (FISH) and immunohistochemistry, and the lymph node was removed surgically. The child was declared to be cured 1 year later. We conclude that adenitis during early childhood may be caused by Marseillevirus.

SUBMITTER: Popgeorgiev N

PROVIDER: S-EPMC3838047 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Marseillevirus adenitis in an 11-month-old child.

Popgeorgiev Nikolay N Michel Gerard G Lepidi Hubert H Raoult Didier D Desnues Christelle C

Journal of clinical microbiology 20131002 12

A Marseillevirus (giant virus of amoeba) has been found in the blood and stool samples of individuals who otherwise appear to be healthy. During an attempt to define a serological cutoff for Marseillevirus by enzyme-linked immunosorbent assay (ELISA) in children, we serendipitously detected high antibody responses to Marseillevirus in an 11-month-old boy suffering from adenitis. Marseillevirus DNA was then found in his blood using PCR and with a unique sequence. We identified Marseillevirus in a ...[more]

PMID: 24088856

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