Discovery and refinement of loci associated with lipid levels.
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ABSTRACT:
SUBMITTER: Willer CJ
PROVIDER: S-EPMC3838666 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Discovery and refinement of loci associated with lipid levels.
Willer Cristen J CJ Schmidt Ellen M EM Sengupta Sebanti S Peloso Gina M GM Gustafsson Stefan S Kanoni Stavroula S Ganna Andrea A Chen Jin J Buchkovich Martin L ML Mora Samia S Beckmann Jacques S JS Bragg-Gresham Jennifer L JL Chang Hsing-Yi HY Demirkan Ayşe A Den Hertog Heleen M HM Do Ron R Donnelly Louise A LA Ehret Georg B GB Esko Tõnu T Feitosa Mary F MF Ferreira Teresa T Fischer Krista K Fontanillas Pierre P Fraser Ross M RM Freitag Daniel F DF Gurdasani Deepti D Heikkilä Kauko K Hyppönen Elina E Isaacs Aaron A Jackson Anne U AU Johansson Åsa Å Johnson Toby T Kaakinen Marika M Kettunen Johannes J Kleber Marcus E ME Li Xiaohui X Luan Jian'an J Lyytikäinen Leo-Pekka LP Magnusson Patrik K E PKE Mangino Massimo M Mihailov Evelin E Montasser May E ME Müller-Nurasyid Martina M Nolte Ilja M IM O'Connell Jeffrey R JR Palmer Cameron D CD Perola Markus M Petersen Ann-Kristin AK Sanna Serena S Saxena Richa R Service Susan K SK Shah Sonia S Shungin Dmitry D Sidore Carlo C Song Ci C Strawbridge Rona J RJ Surakka Ida I Tanaka Toshiko T Teslovich Tanya M TM Thorleifsson Gudmar G Van den Herik Evita G EG Voight Benjamin F BF Volcik Kelly A KA Waite Lindsay L LL Wong Andrew A Wu Ying Y Zhang Weihua W Absher Devin D Asiki Gershim G Barroso Inês I Been Latonya F LF Bolton Jennifer L JL Bonnycastle Lori L LL Brambilla Paolo P Burnett Mary S MS Cesana Giancarlo G Dimitriou Maria M Doney Alex S F ASF Döring Angela A Elliott Paul P Epstein Stephen E SE Ingi Eyjolfsson Gudmundur G Gigante Bruna B Goodarzi Mark O MO Grallert Harald H Gravito Martha L ML Groves Christopher J CJ Hallmans Göran G Hartikainen Anna-Liisa AL Hayward Caroline C Hernandez Dena D Hicks Andrew A AA Holm Hilma H Hung Yi-Jen YJ Illig Thomas T Jones Michelle R MR Kaleebu Pontiano P Kastelein John J P JJP Khaw Kay-Tee KT Kim Eric E Klopp Norman N Komulainen Pirjo P Kumari Meena M Langenberg Claudia C Lehtimäki Terho T Lin Shih-Yi SY Lindström Jaana J Loos Ruth J F RJF Mach François F McArdle Wendy L WL Meisinger Christa C Mitchell Braxton D BD Müller Gabrielle G Nagaraja Ramaiah R Narisu Narisu N Nieminen Tuomo V M TVM Nsubuga Rebecca N RN Olafsson Isleifur I Ong Ken K KK Palotie Aarno A Papamarkou Theodore T Pomilla Cristina C Pouta Anneli A Rader Daniel J DJ Reilly Muredach P MP Ridker Paul M PM Rivadeneira Fernando F Rudan Igor I Ruokonen Aimo A Samani Nilesh N Scharnagl Hubert H Seeley Janet J Silander Kaisa K Stančáková Alena A Stirrups Kathleen K Swift Amy J AJ Tiret Laurence L Uitterlinden Andre G AG van Pelt L Joost LJ Vedantam Sailaja S Wainwright Nicholas N Wijmenga Cisca C Wild Sarah H SH Willemsen Gonneke G Wilsgaard Tom T Wilson James F JF Young Elizabeth H EH Zhao Jing Hua JH Adair Linda S LS Arveiler Dominique D Assimes Themistocles L TL Bandinelli Stefania S Bennett Franklyn F Bochud Murielle M Boehm Bernhard O BO Boomsma Dorret I DI Borecki Ingrid B IB Bornstein Stefan R SR Bovet Pascal P Burnier Michel M Campbell Harry H Chakravarti Aravinda A Chambers John C JC Chen Yii-Der Ida YI Collins Francis S FS Cooper Richard S RS Danesh John J Dedoussis George G de Faire Ulf U Feranil Alan B AB Ferrières Jean J Ferrucci Luigi L Freimer Nelson B NB Gieger Christian C Groop Leif C LC Gudnason Vilmundur V Gyllensten Ulf U Hamsten Anders A Harris Tamara B TB Hingorani Aroon A Hirschhorn Joel N JN Hofman Albert A Hovingh G Kees GK Hsiung Chao Agnes CA Humphries Steve E SE Hunt Steven C SC Hveem Kristian K Iribarren Carlos C Järvelin Marjo-Riitta MR Jula Antti A Kähönen Mika M Kaprio Jaakko J Kesäniemi Antero A Kivimaki Mika M Kooner Jaspal S JS Koudstaal Peter J PJ Krauss Ronald M RM Kuh Diana D Kuusisto Johanna J Kyvik Kirsten O KO Laakso Markku M Lakka Timo A TA Lind Lars L Lindgren Cecilia M CM Martin Nicholas G NG März Winfried W McCarthy Mark I MI McKenzie Colin A CA Meneton Pierre P Metspalu Andres A Moilanen Leena L Morris Andrew D AD Munroe Patricia B PB Njølstad Inger I Pedersen Nancy L NL Power Chris C Pramstaller Peter P PP Price Jackie F JF Psaty Bruce M BM Quertermous Thomas T Rauramaa Rainer R Saleheen Danish D Salomaa Veikko V Sanghera Dharambir K DK Saramies Jouko J Schwarz Peter E H PEH Sheu Wayne H-H WH Shuldiner Alan R AR Siegbahn Agneta A Spector Tim D TD Stefansson Kari K Strachan David P DP Tayo Bamidele O BO Tremoli Elena E Tuomilehto Jaakko J Uusitupa Matti M van Duijn Cornelia M CM Vollenweider Peter P Wallentin Lars L Wareham Nicholas J NJ Whitfield John B JB Wolffenbuttel Bruce H R BHR Ordovas Jose M JM Boerwinkle Eric E Palmer Colin N A CNA Thorsteinsdottir Unnur U Chasman Daniel I DI Rotter Jerome I JI Franks Paul W PW Ripatti Samuli S Cupples L Adrienne LA Sandhu Manjinder S MS Rich Stephen S SS Boehnke Michael M Deloukas Panos P Kathiresan Sekar S Mohlke Karen L KL Ingelsson Erik E Abecasis Gonçalo R GR
Nature genetics 20131006 11
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in hum ...[more]
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