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Pd(0)-catalyzed sequential C-N bond formation via allylic and aromatic C-H amination of ?-methylstyrenes with diaziridinone.

ABSTRACT: A novel Pd(0)-catalyzed sequential C-N bond formation process via allylic and aromatic C-H amination of ?-methylstyrenes with di-tert-butyldiaziridinone, giving spirocyclic indolines in good yields, is described. Four C-N bonds and one spiro quaternary carbon are generated in a single operation.

SUBMITTER: Ramirez TA

PROVIDER: S-EPMC3864675 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Pd(0)-catalyzed sequential C-N bond formation via allylic and aromatic C-H amination of α-methylstyrenes with diaziridinone.

Ramirez Thomas A TA Wang Qian Q Zhu Yingguang Y Zheng Huaiji H Peng Xingao X Cornwall Richard G RG Shi Yian Y

Organic letters 20130806 16

A novel Pd(0)-catalyzed sequential C-N bond formation process via allylic and aromatic C-H amination of α-methylstyrenes with di-tert-butyldiaziridinone, giving spirocyclic indolines in good yields, is described. Four C-N bonds and one spiro quaternary carbon are generated in a single operation. ...[more]

PMID: 23919250

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