Ontology highlight
ABSTRACT:
SUBMITTER: Liu R
PROVIDER: S-EPMC3884031 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Liu Renhe R Winston-McPherson Gabrielle N GN Yang Zhong-Yue ZY Zhou Xin X Song Wangze W Guzei Ilia A IA Xu Xiufang X Tang Weiping W
Journal of the American Chemical Society 20130523 22
Rh(I) carbenes were conveniently generated from readily available ynamides. These metal carbene intermediates could undergo metathesis with electron-rich or neutral alkynes to afford 2-oxopyrrolidines or be trapped by tethered alkenes to yield 3-azabicyclo[3.1.0]hexanes, a common skeleton in numerous bioactive pharmaceuticals. Although the scope of the former is limited, the latter reaction tolerates various substituted alkenes. ...[more]