The somatic genomic landscape of glioblastoma.
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ABSTRACT:
SUBMITTER: Brennan CW
PROVIDER: S-EPMC3910500 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
The somatic genomic landscape of glioblastoma.
Brennan Cameron W CW Verhaak Roel G W RG McKenna Aaron A Campos Benito B Noushmehr Houtan H Salama Sofie R SR Zheng Siyuan S Chakravarty Debyani D Sanborn J Zachary JZ Berman Samuel H SH Beroukhim Rameen R Bernard Brady B Wu Chang-Jiun CJ Genovese Giannicola G Shmulevich Ilya I Barnholtz-Sloan Jill J Zou Lihua L Vegesna Rahulsimham R Shukla Sachet A SA Ciriello Giovanni G Yung W K WK Zhang Wei W Sougnez Carrie C Mikkelsen Tom T Aldape Kenneth K Bigner Darell D DD Van Meir Erwin G EG Prados Michael M Sloan Andrew A Black Keith L KL Eschbacher Jennifer J Finocchiaro Gaetano G Friedman William W Andrews David W DW Guha Abhijit A Iacocca Mary M O'Neill Brian P BP Foltz Greg G Myers Jerome J Weisenberger Daniel J DJ Penny Robert R Kucherlapati Raju R Perou Charles M CM Hayes D Neil DN Gibbs Richard R Marra Marco M Mills Gordon B GB Lander Eric E Spellman Paul P Wilson Richard R Sander Chris C Weinstein John J Meyerson Matthew M Gabriel Stacey S Laird Peter W PW Haussler David D Getz Gad G Chin Lynda L
Cell 20131001 2
We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors, including EGFR and PDGFRA. TERT promoter mutations are shown to correlate with elevated mRNA expression, supporting a role in telomerase reactivation. Correlative analyses confirm that the survival advantage of the proneural subtype is con ...[more]
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