Ontology highlight
ABSTRACT:
SUBMITTER: Steiner NK
PROVIDER: S-EPMC3924325 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Steiner Noriko K NK Dakshanamurthy Sivanesan S Nguyen Nicholas N Hurley Carolyn Katovich CK
Human immunology 20131120 2
Natural killer cell stimulatory receptor gene, KIR2DS5, is polymorphic. While KIR2DS5*002 is most frequently observed, other alleles have also been found. The proteins encoded by these alleles (KIR2DS5*002-*009) are expressed at varying levels on the surface of NKL and Jurkat transfectants. Gel electrophoresis of all allelic products showed two isoforms which differ in the extent of maturation of N-linked glycosylation. These isoforms differed in intensity and molecular weight among the allelic ...[more]