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Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.

ABSTRACT: We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.

SUBMITTER: Lu X 

PROVIDER: S-EPMC3927410 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.

Lu Xiangfeng X   Wang Laiyuan L   Chen Shufeng S   He Lin L   Yang Xueli X   Shi Yongyong Y   Cheng Jing J   Zhang Liang L   Gu C Charles CC   Huang Jianfeng J   Wu Tangchun T   Ma Yitong Y   Li Jianxin J   Cao Jie J   Chen Jichun J   Ge Dongliang D   Fan Zhongjie Z   Li Ying Y   Zhao Liancheng L   Li Hongfan H   Zhou Xiaoyang X   Chen Lanying L   Liu Donghua D   Chen Jingping J   Duan Xiufang X   Hao Yongchen Y   Wang Ligui L   Lu Fanghong F   Liu Zhendong Z   Yao Cailiang C   Shen Chong C   Pu Xiaodong X   Yu Lin L   Fang Xianghua X   Xu Lihua L   Mu Jianjun J   Wu Xianping X   Zheng Runping R   Wu Naqiong N   Zhao Qi Q   Li Yun Y   Liu Xiaoli X   Wang Mengqin M   Yu Dahai D   Hu Dongsheng D   Ji Xu X   Guo Dongshuang D   Sun Dongling D   Wang Qianqian Q   Yang Ying Y   Liu Fangchao F   Mao Qunxia Q   Liang Xiaohua X   Ji Jingfeng J   Chen Panpan P   Mo Xingbo X   Li Dianjiang D   Chai Guoping G   Tang Yida Y   Li Xiangdong X   Du Zhenhan Z   Liu Xuehui X   Dou Chenlong C   Yang Zili Z   Meng Qingjie Q   Wang Dong D   Wang Renping R   Yang Jun J   Schunkert Heribert H   Samani Nilesh J NJ   Kathiresan Sekar S   Reilly Muredach P MP   Erdmann Jeanette J   Peng Xiaozhong X   Wu Xigui X   Liu Depei D   Yang Yuejin Y   Chen Runsheng R   Qiang Boqin B   Gu Dongfeng D  

Nature genetics 20120701 8

We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European  ...[more]

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