Ontology highlight
ABSTRACT:
SUBMITTER: Jiang K
PROVIDER: S-EPMC4741898 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Oncotarget 20151101 37
Genome-wide association studies (GWAS) have reported a number of loci harboring common variants that influence risk of colorectal cancer (CRC) in European descent. But all the SNPs identified explained a small fraction of total heritability. To identify more genetic factors that modify the risk of CRC, especially Chinese Han specific, we conducted a three-stage GWAS including a screening stage (932 CRC cases and 966 controls) and two independent validations (Stage 2: 1,759 CRC cases and 1,875 co ...[more]