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Ultrafast Z-Spectroscopy for (129)Xe NMR-Based Sensors.

ABSTRACT: When working with hyperpolarized species, it is often difficult to maintain a stable level of magnetization over consecutive experiments, which renders their detection at the trace level cumbersome, even when combined with chemical exchange saturation transfer (CEST). We report herein the use of ultra-fast Z-spectroscopy as a powerful means to detect low concentrations of (129)Xe NMR-based sensors and to measure the in-out xenon exchange. Modifications of the original sequence enable a multiplexed detection of several sensors, as well as the extraction of the exchange buildup rate constant in a single-shot fashion.

SUBMITTER: Boutin C

PROVIDER: S-EPMC3927827 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Ultrafast Z-Spectroscopy for 129Xe NMR-Based Sensors.

Boutin Céline C Léonce Estelle E Brotin Thierry T Jerschow Alexej A Berthault Patrick P

The journal of physical chemistry letters 20131201 23

When working with hyperpolarized species, it is often difficult to maintain a stable level of magnetization over consecutive experiments, which renders their detection at the trace level cumbersome, even when combined with chemical exchange saturation transfer (CEST). We report herein the use of ultra-fast Z-spectroscopy as a powerful means to detect low concentrations of 129Xe NMR-based sensors and to measure the in-out xenon exchange. Modifications of the original sequence enable a ...[more]

PMID: 24563724

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