Ontology highlight
ABSTRACT:
SUBMITTER: Campbell MG
PROVIDER: S-EPMC3939929 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Campbell Melody G MG Underbakke Eric S ES Potter Clinton S CS Carragher Bridget B Marletta Michael A MA
Proceedings of the National Academy of Sciences of the United States of America 20140210 8
Soluble guanylate cyclase (sGC) is the primary nitric oxide (NO) receptor in mammals and a central component of the NO-signaling pathway. The NO-signaling pathways mediate diverse physiological processes, including vasodilation, neurotransmission, and myocardial functions. sGC is a heterodimer assembled from two homologous subunits, each comprised of four domains. Although crystal structures of isolated domains have been reported, no structure is available for full-length sGC. We used single-par ...[more]