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Immunology of age-related macular degeneration.

ABSTRACT: Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.

SUBMITTER: Ambati J

PROVIDER: S-EPMC3941009 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Immunology of age-related macular degeneration.

Ambati Jayakrishna J Atkinson John P JP Gelfand Bradley D BD

Nature reviews. Immunology 20130601 6

Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD ...[more]

PMID: 23702979

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Age-related macular degeneration.

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