Ontology highlight
ABSTRACT:
SUBMITTER: Chaurasiya KR
PROVIDER: S-EPMC3950479 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Chaurasiya Kathy R KR McCauley Micah J MJ Wang Wei W Qualley Dominic F DF Wu Tiyun T Kitamura Shingo S Geertsema Hylkje H Chan Denise S B DS Hertz Amber A Iwatani Yasumasa Y Levin Judith G JG Musier-Forsyth Karin K Rouzina Ioulia I Williams Mark C MC
Nature chemistry 20131124 1
The human APOBEC3 proteins are a family of DNA-editing enzymes that play an important role in the innate immune response against retroviruses and retrotransposons. APOBEC3G is a member of this family that inhibits HIV-1 replication in the absence of the viral infectivity factor Vif. Inhibition of HIV replication occurs by both deamination of viral single-stranded DNA and a deamination-independent mechanism. Efficient deamination requires rapid binding to and dissociation from ssDNA. However, a r ...[more]