Ontology highlight
ABSTRACT:
SUBMITTER: Nelp MT
PROVIDER: S-EPMC4767005 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20150717 36
The biosynthesis of nitriles is known to occur through specialized pathways involving multiple enzymes; however, in bacterial and archeal biosynthesis of 7-deazapurines, a single enzyme, ToyM, catalyzes the conversion of the carboxylic acid containing 7-carboxy-7-deazaguanine (CDG) into its corresponding nitrile, 7-cyano-7-deazaguanine (preQ0 ). The mechanism of this unusual direct transformation was shown to proceed via the adenylation of CDG, which activates it to form the newly discovered ami ...[more]