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Simple, chemoselective hydrogenation with thermodynamic stereocontrol.

ABSTRACT: Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.

SUBMITTER: Iwasaki K

PROVIDER: S-EPMC3951266 | biostudies-literature |

REPOSITORIES: biostudies-literature

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