Associations of genetic risk score with obesity and related traits and the modifying effect of physical activity in a Chinese Han population.

ABSTRACT:

Background/objectives

Recent large-scale genome-wide association studies have identified multiple loci robustly associated with BMI, predominantly in European ancestry (EA) populations. However, associations of these loci with obesity and related traits have not been well described in Chinese Hans. This study aimed to investigate whether BMI-associated loci are, individually and collectively, associated with adiposity-related traits and obesity in Chinese Hans and whether these associations are modified by physical activity (PA).

Subjects/methods

We genotyped 28 BMI-associated single nucleotide polymorphisms (SNPs) in a population-based cohort including 2,894 unrelated Han Chinese. Genetic risk score (GRS), EA and East Asian ancestry (EAA) GRSs were calculated by adding BMI-

SUBMITTER: Zhu J 

PROVIDER: S-EPMC3953410 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature