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Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer.

ABSTRACT: Gastric gland mucin is secreted from gland mucous cells, including pyloric gland cells and mucous neck cells located in the lower layer of the gastric mucosa. These mucins typically contain O-glycans carrying terminal ?1,4-linked N-acetylglucosamine residues (?GlcNAc) attached to the scaffold protein MUC6, and biosynthesis of the O-glycans is catalyzed by the glycosyltransferase, ?1,4-N-acetylglucosaminyltransferase (?4GnT). We previously used expression cloning to isolate cDNA encoding ?4GnT, and then demonstrated that ?GlcNAc functions as natural antibiotic against Helicobacter pylori, a microbe causing various gastric diseases including gastric cancer. More recently, it was shown that ?GlcNAc serves as a tumor suppressor for differentiated-type adenocarcinoma. This review summarizes these findings and identifies dual roles for ?GlcNAc in gastric cancer.

SUBMITTER: Nakayama J

PROVIDER: S-EPMC3972424 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer.

Nakayama Jun J

Acta histochemica et cytochemica 20140218 1

Gastric gland mucin is secreted from gland mucous cells, including pyloric gland cells and mucous neck cells located in the lower layer of the gastric mucosa. These mucins typically contain O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc) attached to the scaffold protein MUC6, and biosynthesis of the O-glycans is catalyzed by the glycosyltransferase, α1,4-N-acetylglucosaminyltransferase (α4GnT). We previously used expression cloning to isolate cDNA encoding α4GnT, a ...[more]

PMID: 24761044

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